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Test Code (รหัสการทดสอบ):
FSH

Order Name (ชื่อการทดสอบ):
FSH (Follicle Stimulating Hormone)

 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours
 
Useful For (ประโยชน์การทดสอบ):
Determination of follicle stimulating hormone (FSH) in human serum.
 
 
Methodology (วิธีการทดสอบ):
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName (ชื่อเรียกอื่นๆ) :
Follicle Stimulating Hormone
 
 
 
Test Code (รหัสการทดสอบ):
FSH

Order Name (ชื่อการทดสอบ):
FSH (Follicle Stimulating Hormone)

 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 1 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: 4+ reject
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 8 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -10oC or colder 12 months
 
 
 
Test Code (รหัสการทดสอบ):
FSH

Order Name (ชื่อการทดสอบ):
FSH (Follicle Stimulating Hormone)

 
Method detail (วิธีการทดสอบ):
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule (ตารางการทดสอบ):
Tested daily (24 hours)
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
FSH

Order Name (ชื่อการทดสอบ):
FSH (Follicle Stimulating Hormone)

 
 
Clinical Information (ข้อมูลทางคลินิก):
Human Follicle Stimulating Hormone (FSH, follitropin) is a glycoprotein of approximately 30,000 daltons which, like luteinizing hormone (LH, lutropin), human chorionic gonadotropin (hCG) and thyroid stimulating hormone (TSH, thyrotropin), consists of two noncovalently associated subunits designated α and β.  The α subunit of FSH contains 92 amino acids and is very similar to the α subunits of LH, hCG, and TSH.  The β subunit of FSH is unique and confers its immunological and functional specificity. 

FSH and LH control growth and reproductive activities of the gonadal tissues.  FSH promotes follicular development in the ovary and gametogenesis in the testis.  The gonadotroph cells of the anterior pituitary secrete both FSH and LH in response to gonadotropin releasing hormone (LHRH or GnRH) from the medial basal hypothalamus.  Both FSH and LH are secreted in a pulsatile manner, with rapid fluctuations over the normal range. The pulsatility of FSH is less pronounced than that of LH. Release of both FSH and LH from the pituitary is under negative feedback control by the gonads. 

FSH in mature females acts to stimulate development of the ovarian follicles. Circulating FSH levels vary throughout the menstrual cycle in response to estradiol and progesterone. A small, but significant increase
in circulating FSH accompanies the mid-cycle LH surge. However, the physiological significance of this increase is unknown. Circulating levels of FSH decline in the luteal phase in response to estradiol and progesterone
production by the developing corpus luteum. 

At menopause, ovarian function is diminished with concomitant decrease in estradiol secretion. FSH and LH then increase significantly in response to diminished feedback inhibition of gonadotropin release.  In males,
FSH, LH, and testosterone regulate spermatogenesis by the Sertoli cells in the seminiferous tubules of the testes. FSH is less sensitive to feedback inhibition by testosterone than is LH and is thought to be regulated
independently by the inhibitory peptide inhibin produced by the Sertoli cells. 

Because of the negative feedback mechanisms regulating gonadotropin release, elevated concentrations of LH and FSH are indicative of gonadal failure when accompanied by low concentrations of the gonadal steroids. In males, these observations suggest primary testicular failure or anorchia.  FSH may also be elevated in Klinefelter’s syndrome (seminiferous tubule dysgenesis) or as a consequence of Sertoli cell failure.  In females, situations in which FSH is elevated and gonadal steroids are depressed include menopause, premature ovarian failure, and ovariectomy, while with polycystic ovarian syndrome the LH/FSH ratio may be increased.

Abnormal FSH concentrations may also indicate dysfunction of the hypothalamic-pituitary axis. In sexually mature adults, FSH deficiency, together with low concentrations of LH and sex steroids, may indicate panhypopituitarism.  This can result either from a decrease in the release of GnRH or from a lack of response of the pituitary to GnRH. Determination of serum FSH, following administration of GnRH, may allow differentiation
of these two conditions. The use of oral contraceptives usually results in reduction of gonadotropin levels due to negative feedback by these steroids.
 
Reference Value (ค่าอ้างอิง):
FSH
Sex Reference value Unit
Male 0.95 - 11.95 mIU/mL
Normale Menstruating Females Follicular phase 3.03 - 8.08 mIU/mL
Mid-cycle peak 2.55 - 16.69 mIU/mL
Luteal phase 1.38 - 5.47 mIU/mL
Post-Menopausal Females 26.72 - 133.41 mIU/mL
 
 
Clinical Reference (เอกสารอ้างอิง):
Manufacturer’s Reagent package insert Architect FSH, Abbott Ireland Diagnostic Division, Lisnamuck, Longford Co.,Longford,Ireland