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HomeLab Services GuideTests
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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
FOL
Order Name (ชื่อการทดสอบ):
Folic Acid*
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood 6 mL (Red Top) 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours
 
Useful For (ประโยชน์การทดสอบ):
Determination of folate in human serum
 
Methodology (วิธีการทดสอบ):
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
AliasesName (ชื่อเรียกอื่นๆ) :
Folate 
 
 
 
Test Code (รหัสการทดสอบ):
FOL
Order Name (ชื่อการทดสอบ):
Folic Acid*
 
Patient Preparation (การเตรียมตัวผู้ป่วย):
Patient should be fasting at least 8 hours
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood 6 mL (Red Top) 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 1 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: Mild or above reject
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum (keep in original tube) Refrigerated, 2oC to 8oC 72 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -10oC 30 days
 
 
 
Test Code (รหัสการทดสอบ):
FOL
Order Name (ชื่อการทดสอบ):
Folic Acid*
 
Method detail (วิธีการทดสอบ):
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule (ตารางการทดสอบ):
Tested daily (24 hours)
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
FOL
Order Name (ชื่อการทดสอบ):
Folic Acid*
 
 
Clinical Information (ข้อมูลทางคลินิก):
Folates are a class of vitamin compounds related to pteroylglutamic acid (PGA), which serve as cofactors in the enzymatic transfer of single carbon units in a variety of metabolic pathways. Folate mediated one-carbon
metabolism represents one of the most important biochemical reactions that occur in cells. Folates are necessary for nucleic acid and mitochondrial protein synthesis, amino acid metabolism, and other cellular processes that involve single carbon transfers. Folates can serve as carbon donors or acceptors. Since different metabolic pathways require carbon groups with different levels of oxidation, cells contain numerous enzymes that change the oxidation state of carbon groups carried by folates  resulting in different metabolically active forms of folate. The predominant form of circulating folate is 5-methyltetrahydrofolic acid (5-mTHF). A methyl
group is transferred from 5-mTHF to cobalamin in the pathway that links metabolism of folic acid and vitamin B12. 

Folate deficiency can be caused by low dietary intake, malabsorption due to gastrointestinal diseases, inadequate utilization due to enzyme deficiencies or folate antagonist therapy, drugs such as alcohol and
oral contraceptives, and excessive folate demand, such as during pregnancy. Because deficiencies of both vitamin B12 and folate can lead to megaloblastic (macrocytic) anemia, appropriate treatment requires
differential diagnosis of the deficiency; thus, both vitamin B12 and folate values are needed. Low serum folate levels reflect the first stage of negative folate balance, and precede tissue depletion.  Low red-blood-cell folate values reflect the second stage of negative folate balance, and more closely correlate with tissue levels and megaloblastic anemia.
 
Reference Value (ค่าอ้างอิง):
3.1- 20.5 ng/mL 
 
Clinical Reference (เอกสารอ้างอิง):
1. Manufacturer’s Reagent package insert Architect Folate,  Abbott Ireland, Diagnostics Division Lisnamuck Longford Co., Ireland.
2. Patient Preparation: https://www.mayocliniclabs.com (Retrieved: Jan 2019)