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HomeLab Services GuideTests
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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
ACTH
Order Name (ชื่อการทดสอบ):
ACTH (Adrenocorticotrophic Hormone) **
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ EDTA (Lavender top) 3 mL, 2 tubes

Sent to Laboratory within 15 minutes after collect
 
Turnaround Time (ระยะเวลารอผล):
Received specimen to reported within 2 days
(exception for official holidays)
 
Useful For (ประโยชน์การทดสอบ):
Determining the cause of hypercortisolism and hypocortisolism.
Help to evaluate adrenal insufficiency and hypersecretion such as Addison's disease, Cushing's syndrome patient with cortisol hypersecretion.
 
Methodology (วิธีการทดสอบ):
Electrochemiluminescense immunoassay (ECLIA)
 
AliasesName (ชื่อเรียกอื่นๆ) :
ACTH (Adrenocorticotropic Hormone)
ACTH (Corticotropin)
Adrenal Corticotropin Hormone
Corticotropin
Cushing's Disease
Cortrosyn
 
 
 
Test Code (รหัสการทดสอบ):
ACTH
Order Name (ชื่อการทดสอบ):
ACTH (Adrenocorticotrophic Hormone) **
 
Patient Preparation (การเตรียมตัวผู้ป่วย):
For the 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ EDTA (Lavender top) 3 mL, 2 tubes

Sent to Laboratory within 15 minutes after collect
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
EDTA plasma, minimum volume 3-5 mL (Ship Frozen)
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic tube
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis - Reject

 
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Plasma EDTA Refrigerated, 2oC to 8oC  3 hrs.
Plasma EDTA Frozen (preferred) 28 days

 
 
 
 
Test Code (รหัสการทดสอบ):
ACTH
Order Name (ชื่อการทดสอบ):
ACTH (Adrenocorticotrophic Hormone) **
 
Method detail (วิธีการทดสอบ):
Electrochemiluminescense immunoassay (ECLIA)
 
Schedule (ตารางการทดสอบ):
N/A **Sent Out to Chulalongkorn
 
Turnaround Time (ระยะเวลารอผล):
Received specimen to reported within 2 days
(exception for official holidays)
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
CMDL, Chulalongkorn
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code (รหัสการทดสอบ):
ACTH
Order Name (ชื่อการทดสอบ):
ACTH (Adrenocorticotrophic Hormone) **
 
 
Clinical Information (ข้อมูลทางคลินิก):
Adrenocorticotropic hormone (ACTH) is synthesized by the pituitary in response to corticotropin-releasing hormone (CRH), which is released by the hypothalamus. ACTH stimulates adrenal cortisol production. Plasma ACTH and cortisol levels exhibit peaks (6-8 a.m.) and troughs (11 p.m.).
 
Reference Value (ค่าอ้างอิง):
7.2 - 63.3 pg/mL
 
Interpretation (การแปลผล):

In a patient with hypocortisolism, an elevated adrenocorticotropic hormone (ACTH) indicates primary adrenal insufficiency, whereas a value that is not elevated is consistent with secondary adrenal insufficiency from a pituitary or hypothalamic cause.

In a patient with hypercortisolism (Cushing syndrome), a suppressed value is consistent with a cortisol-producing adrenal adenoma or carcinoma, primary adrenal micronodular hyperplasia, or exogenous corticosteroid use.

Normal or elevated ACTH in a patient with Cushing syndrome puts the patient in the ACTH-dependent Cushing syndrome category. This is due to either an ACTH-producing pituitary adenoma or ectopic production of ACTH (bronchial carcinoid, small cell lung cancer, others). Further diagnostic studies such as dexamethasone suppression testing, corticotropin-releasing hormone stimulation testing, petrosal sinus sampling, and imaging studies are usually necessary to define the ACTH source.

ACTH concentrations vary considerably depending on physiological conditions. Therefore, ACTH results should always be evaluated with simultaneously measured cortisol concentrations.

 
Clinical Reference (เอกสารอ้างอิง):
  1. https://cmdl.md.chula.ac.th (Retrieved: 27 May 2020) 
  2. www.mayomedicallaboratories.com (Retrieved: 27 May 2020)