Clinical Information (ข้อมูลทางคลินิก):
Apolipoprotein E (ApoE) locates on 19q13.2 and consists of 299 amino in length. It plays an important role in cholesterol transportation and metabolism. Three most common alleles of ApoE are e3 (Cys112/Arg158), e2(Cys112/Cys158) and e4(Arg112/Arg158). Among these three alleles, e3 is the wildtype and most commonly found. Mutation in ApoE might increase or decrease the risk for Alzheimer’s disease. Individuals with APOE e3/e4 genotype have a three-to-four-fold relative risk while individuals with APOE e4/e4 genotype have a 15-fold relative risk compared to those with the APOE e3/e3 genotype. Other than the risk at Late-onset Alzheimer developing, these mutations are related with the age of onset for the disease. The average age of developing Late-onset Alzheimer is 68 years at 94% for HomozygyousE4, 76 years at 47% frequency for hetrozygousE4 and 84 years at 20% frequency for those who do not carry E4.
Clinical Reference (เอกสารอ้างอิง):
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