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HomeLab Services GuideTests
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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
092-10-0085
Order Name (ชื่อการทดสอบ):
APOE Cardio report (WES add-on panel)
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Specimen: Not required

Document required: Consent for Genomic Medicine Testing
 
Turnaround Time (ระยะเวลารอผล):
Report within 2 weeks
 
Useful For (ประโยชน์การทดสอบ):
Healthy people who are interested to know about the risk of APOE gene for developing Cardiovascular Disease.
 
Methodology (วิธีการทดสอบ):
Data analysis using Whole Exome Sequencing (WES) data
 
Test List In Profile (การทดสอบใน Profile):
APOE Cardio report
 
AliasesName (ชื่อเรียกอื่นๆ) :
whole exome sequencing, WES, APOE, Cardio
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0085
Order Name (ชื่อการทดสอบ):
APOE Cardio report (WES add-on panel)
 
Patient Preparation (การเตรียมตัวผู้ป่วย):
Patient must has Whole exome sequencing (WES) before order this test
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Specimen: Not required

Document required: Consent for Genomic Medicine Testing
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Not required
 
Sub Mission Container (ภาชนะส่งตรวจ):
N/A
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0085
Order Name (ชื่อการทดสอบ):
APOE Cardio report (WES add-on panel)
 
Turnaround Time (ระยะเวลารอผล):
Report within 2 weeks
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Research and Development laboratory, Tel 14152
 
 
 
Test Code (รหัสการทดสอบ):
092-10-0085
Order Name (ชื่อการทดสอบ):
APOE Cardio report (WES add-on panel)
 
 
Clinical Information (ข้อมูลทางคลินิก):
Apolipoprotein E (ApoE) locates on 19q13.2 and consists of 299 amino in length. It plays an important role in cholesterol transportation and metabolism. Three most common alleles of ApoE are e3 (Cys112/Arg158), e2(Cys112/Cys158) and e4(Arg112/Arg158). Among these three alleles, e3 is the wildtype and most commonly found. Mutation in ApoE might increase or decrease the risk for cardiovascular disease.
 
Clinical Reference (เอกสารอ้างอิง):
1. Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 2002 Mar 15;155(6):487-95. 
2. Schaefer EJ, Lamon-Fava S, Johnson S, Ordovas JM, Schaefer MM, Castelli WP, Wilson PW. Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. Arterioscler Thromb. 1994 Jul;14(7):1105-13. 
3. Song Y, Stampfer MJ, Liu S. Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med. 2004 Jul 20;141(2):137-47. 
4. Goldman JS, Hahn SE, Catania JW, LaRusse-Eckert S, Butson MB, Rumbaugh M, Strecker MN, Roberts JS, Burke W, Mayeux R, Bird T; American College of Medical Genetics and the National Society of Genetic Counselors. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med. 2011 Jun;13(6):597-605. 
5. Van Cauwenberghe C, Van Broeckhoven C, Sleegers K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet Med. 2016 May;18(5):421-30. 
6. Li Z, Shue F, Zhao N, Shinohara M, Bu G. APOE2: protective mechanism and therapeutic implications for Alzheimer's disease. Mol Neurodegener. 2020 Nov 4;15(1):63.