090-30-0310-01

CMV IgM (Cytomegalovirus Antibody, IgM)

Blood/ Plain Blood (Red Top) 6 mL, 1 tube

Serum, minimum volume 2 mL

Plastic vial

Hemolysis: 4+ reject

Specimen Type	Temperature	Time
Serum (keep in original tube)	Room temperature, 20oC to 28oC	8 hours
Serum	Refrigerated, 2oC to 8oC	14 days
	Frozen , 10oC	> 14 days

090-30-0310-01

CMV IgM (Cytomegalovirus Antibody, IgM)

Chemiluminescent Microparticle Immuno Assay (CMIA)

Tested Daily (24 Hours)

Specimen collected to reported within 2 Hours

Immunology, Laboratory Department Tel. 13227

5 days

090-30-0310-01

CMV IgM (Cytomegalovirus Antibody, IgM)

Infections with Cytomegalovirus (CMV). a member of the herpesvirus family, are common in man and are usually mild and asymptomatic. However in pregnant women,' newborns," and immunocompromised
individuals. CMV infections may pose a significant medical risk.  CMV infection remains difficult to diagnose on symptoms alone since a high percentage of infections remain without symptoms. In utero infection may result in sequelae of varying degree including mental retardation. chorioretinitis. hearing loss and neurological
problems. Since the risk of in utero virus transmission and CMV related damage of the fetus is strongly increased during primary infection, reliable recognition of primary CMV infections is of high importance for pregnant women. Reinfection with exogenous virus or reactivation of latent virus may lead to the presence of anti-CMV IgM in absence of a primary CMV infection. Although presence of anti-CMV IgG reduces the likelihood of CMV related complications, it does not assure complete protection from disease.
CMV acquisition in infants can occur transplacentally following maternal infection, during birth by contact with the virus excreted from the cervixB or following birth through the ingestion of Infected maternal breast milk. Both seronegative individuals and infants may acquire CMV through infected blood products'' or contact with an infected individual. Children beyond the neonatal period are susceptible to infection and subsequent transmission of CMV when in day care.
If primary infection needs to be excluded, CMV IgG reactive samples should be tested for CMV IgM and CMV IgG Avidity. A positive CMV IgM result in connection with low avidity result is a strong indicator of a primary CMV infection Within the last 4 months. 

Non reactive

Manufacturer’s Reagent package insert, Architect CMV IgM, Abbott Ireland Diagnostics Division, Finisklin Business Park, Sligo, Ireland.