bih.button.backtotop.text
HomeLab Services GuideTests
BROWSE BY TEST NAME
#
%
1
2
3
5
8
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Z
Clear
Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
090-81-2027
Order Name (ชื่อการทดสอบ):
Encephalopathy, Autoimmune (Paraneoplastic) Evaluation, CSF (MAYO) **
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
CSF 4 mL / Sterile Container

NECESSARY INFORMATION
Provide the following information:
-Relevant clinical information
-Ordering provider name, phone number, mailing address, and e-mail address
 
Turnaround Time (ระยะเวลารอผล):
21 days
 
Useful For (ประโยชน์การทดสอบ):
Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation using spinal fluid specimens.

This test is designed for patients age 18 and older.
 
Methodology (วิธีการทดสอบ):
- Indirect Immunofluorescence Assay (IFA)
- Cell Binding Assay (CBA)
- Western Blot (WB)
- Immunoblot (IB)
- Radioimmunoassay (RIA)
- Medical Interpretation
 
 
AliasesName (ชื่อเรียกอื่นๆ) :
Encephalopathy, Interpretation, CSF
AMPA-R Ab CBA, CSF
Amphiphysin Ab, CSF
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
CASPR2-IgG CBA, CSF
CRMP-5-IgG, CSF
DPPX Ab CBA, CSF
GABA-B-R Ab CBA, CSF
GAD65 Ab Assay, CSF
GFAP IFA, CSF
mGluR1 Ab IFA, CSF
IgLON5 CBA, CSF
LGI1-IgG CBA, CSF
Neurochondrin IFA, CSF
NIF IFA, CSF
NMDA-R Ab CBA, CSF
Purkinje Cell Cytoplasmc Ab Type Tr
Purkinje Cell Cytoplasmic Ab Type 1
Purkinje Cell Cytoplasmic Ab Type 2
PDE10A Ab IFA, CSF
Septin-7 IFA, CSF
TRIM46 Ab IFA, CSF

Plus auto-reflex as algorithm
 
 
 
Test Code (รหัสการทดสอบ):
090-81-2027
Order Name (ชื่อการทดสอบ):
Encephalopathy, Autoimmune (Paraneoplastic) Evaluation, CSF (MAYO) **
 
Patient Preparation (การเตรียมตัวผู้ป่วย):
This test is intended to be ordered for adult patients (age 18 and older only).
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
CSF 4 mL / Sterile Container

NECESSARY INFORMATION
Provide the following information:
-Relevant clinical information
-Ordering provider name, phone number, mailing address, and e-mail address
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
CSF, minimum volume 2 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Sterile vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Gross hemolysis
Gross lipemia
Gross icterus
Patient age under 18
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
CSF: 
- Refrigerated 28 days    
- Frozen     28 days    
- Ambient 72 hours
 
 
 
Test Code (รหัสการทดสอบ):
090-81-2027
Order Name (ชื่อการทดสอบ):
Encephalopathy, Autoimmune (Paraneoplastic) Evaluation, CSF (MAYO) **
 
Schedule (ตารางการทดสอบ):
N/A **Sent out to MAYO, USA
 
Turnaround Time (ระยะเวลารอผล):
21 days
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
MAYO Laboratory
Referral Lab Services, Laboratory Department 14160-2
 
 
 
Test Code (รหัสการทดสอบ):
090-81-2027
Order Name (ชื่อการทดสอบ):
Encephalopathy, Autoimmune (Paraneoplastic) Evaluation, CSF (MAYO) **
 
 
Clinical Information (ข้อมูลทางคลินิก):
Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomias, or hypoventilation using spinal fluid specimens

The following accompaniments should increase of suspicion for autoimmune encephalopathy:
-Headache
-Autoimmune stigmata (personal or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)
-History of cancer
-Smoking history (20 or more pack-years) or other cancer risk factors
-Inflammatory cerebrospinal fluid (or isolated protein elevation)
-Neuroimaging signs suggesting inflammation

Evaluating limbic encephalitis (noninfectious)

Directing a focused search for cancer

Investigating encephalopathy appearing during or after cancer therapy and not explainable by metastasis or drug effect
 
Reference Value (ค่าอ้างอิง):
The interpete report will be provided
 
Interpretation (การแปลผล):
INTERPRETATION 
Neuronal, glial, and muscle autoantibodies are valuable serological markers of autoimmune encephalopathy and of a patient's immune response to cancer. These autoantibodies are usually accompanied by subacute neurological symptoms and signs are not found in healthy subjects. It is not uncommon for more than 1 of the following autoantibody specificities to be detected in patients with an autoimmune encephalopathy:
-Plasma membrane autoantibodies: These are all potential effectors of neurological dysfunction: N-methyl-D-aspartate (NMDA) receptor; 2-amino-3-(5-methyl-3-oxo-1,2- oxazol-4-yl) propanoic acid (AMPA) receptor; gamma-amino butyric acid (GABA-B) receptor; neuronal acetylcholine receptor.
-Neuronal nuclear autoantibodies: type 1 (ANNA-1), type 2 (ANNA-2), or type 3 (ANNA-3)
-Neuronal or muscle cytoplasmic antibodies: amphiphysin, Purkinje cell antibodies (PCA-1 and PCA-2), collapsin response-mediator protein-5 (CRMP-5), or glutamic acid decarboxylase (GAD65).

CAUTIONS 
Negative results do not exclude autoimmune encephalopathy or cancer.
 
This test does not detect Ma1 or Ma2 antibodies (also known as MaTa), which are sometimes associated with brainstem and limbic encephalitis in the context of testicular germ cell neoplasms. Scrotal ultrasound is advised for men who present with unexplained subacute encephalitis.
 
Clinical Reference (เอกสารอ้างอิง):
www.mayomedicallaboratories.com (Retrieved: 22 Jul 2024)