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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
090-30-2332-01
Order Name (ชื่อการทดสอบ):
HE4
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Plain Blood 6 mL (Red Top) 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours 
 
Useful For (ประโยชน์การทดสอบ):
Used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical methods used for monitoring ovarian cancer. It is further intended to be used in conjunction with CA 125 as an aid in estimating the risk of epithelial ovarian cancer in premenopausal and postmenopausal women presenting with an adnexal mass who will
undergo surgical intervention. The results must be interpreted in conjunction with other methods in accordance with standard clinical management guidelines.
 
Methodology (วิธีการทดสอบ):
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
 
 
Test Code (รหัสการทดสอบ):
090-30-2332-01
Order Name (ชื่อการทดสอบ):
HE4
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Plain Blood 6 mL (Red Top) 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 0.5 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum (keep in original tube) Room Temperature 8 hours
Serum Refrigerated, 2oC to 8oC 4 days
Frozen, -10oC > 4 days
 
 
 
Test Code (รหัสการทดสอบ):
090-30-2332-01
Order Name (ชื่อการทดสอบ):
HE4
 
Method detail (วิธีการทดสอบ):
Chemiluminescent Microparticle Immuno Assay (CMIA)
 
Schedule (ตารางการทดสอบ):
Tested daily (24 hours)
 
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 2 hours 
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Immunology, Laboratory Department Tel. 13227
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
090-30-2332-01
Order Name (ชื่อการทดสอบ):
HE4
 
 
Clinical Information (ข้อมูลทางคลินิก):
Human epididymis protein 4 (HE4) belongs to the family of whey acidic four-disulfide core (WFDC) proteins. Currently, the biologic function of HE4 is unknown.
HE4 has been shown to be overexpressed in 93% of serous, 100% of endometrioid, and 50% of clear cell ovarian carcinomas. In a study of 233 patients with a pelvic mass, including 67 with epithelial ovarian cancer, HE4 had a higher sensitivity for ovarian cancer detection than cancer antigen 125 (CA 125), 72.9% versus 43.3%, respectively, at a specificity of 95%. Researchers also found HE4 to be elevated in more than half of the ovarian cancer patients who did not have elevated CA 125 levels; therefore, the combination of markers provided slightly improved cancer diagnostic sensitivity for the detection of ovarian cancer.
The main established application of HE4 is in post-therapy monitoring of ovarian cancer patients, who had elevated pretreatment levels. In this setting, it complements CA 125 measurement and facilitates follow-up of patients with little or no CA 125 pretreatment elevations.
Certain histological types of ovarian cancer (mucinous or germ cell tumors) rarely express HE4, therefore the use of HE4 is not recommended for monitoring of patients with these types of ovarian cancer.
 
Reference Value (ค่าอ้างอิง):
For premenopausal patient = 0-70 pmol/L
For postmenopausal patient = 0-140 pmol/L
 
Clinical Reference (เอกสารอ้างอิง):
1. Manufacturer’s Reagent package insert Architect HE4, Abbott GmbH &Co.KG, MAX-Planck-Ring 2, 65205 Wiesbaden, Germany.
2. www.mayoclinic.com (Retreived : Jan 2021)