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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก

Test Code (รหัสการทดสอบ):

090-71-5552

Order Name (ชื่อการทดสอบ):

INVITAE Cancer screen (Proactive test) **

Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):

Blood/ K3 EDTA (Lavender Top) 6 mL, 1 tube

Document Required:
1. Completed Consent Form LAB-08170-Rev04-EN-Consent-for-Genomic-Medicine-Testing.pdf
2. Completed Requisition Form LAB-REQ02-Rev02-0206_INVITAE-Proactive.pdf

Turnaround Time (ระยะเวลารอผล):

30 days

Useful For (ประโยชน์การทดสอบ):

Adult (อายุ 18 ปีขึ้นไป) who wants to optimize their health by knowing their personal genetic risk of cancer. With that knowledge, action can be taken to prevent the onset of disease.

If you checked "No" to all questions, your patient is likely a good candidate for Proactive genetic testing. If you checked "Yes" for any of the boxes above, you may want to consider further evaluation to determine whether Diagnostic testing is more appropriate for your patient.

Do any of the following apply to your patient or their close blood relative* ?

Early-onset breast cancer (at age 45 or younger), triple-negative breast cancer (ER-, PR-, HER2-; at age 60 or younger), breast cancer in a male, or breast cancer in an individual with Ashkenazi Jewish ancestry
Ovarian cancer
Colorectal cancer or endometrial cancer (younger than age 50) Diffuse gastric cancer
Metastatic prostate cancer
Pancreatic cancer
10 or more colon polyps

*Close blood relatives include sibling, half-sibling, parent, child, aunt/uncle, niece/nephew, grandparent, or grandchild

Methodology (วิธีการทดสอบ):

Next-generation sequencing (NGS)

Test List In Profile (การทดสอบใน Profile):

APC ATM AXIN2 BAP1 BARD1 BMPR1A BRCA1 BRCA2 BRIP1 CDC73 CDH1 CDK4 CDKN2A CHEK2 DICER1 EPCAM FH FLCN GREM1 HOXB13 KIT MAX MEN1 MET MITF MLH1 MSH2 MSH3 MSH6 MUTYH NBN NF1 NF2 NTHL1 PALB2 PDGFRA PMS2 POLD1 POLE PRKAR1A PTCH1 PTEN RAD51C RAD51D RB1 RET SDHA SDHAF2 SDHB SDHC SDHD SMAD4 SMARCA4 SMARCB1 STK11 TMEM127 TP53 TSC1 TSC2 VHL WT1

Test Code (รหัสการทดสอบ):

090-71-5552

Order Name (ชื่อการทดสอบ):

INVITAE Cancer screen (Proactive test) **

Patient Preparation (การเตรียมตัวผู้ป่วย):

Genetics Counseling
ไม่ทำการตรวจ Proactive ในผู้ที่อายุต่ำกว่า 18 ปี

Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):

Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):

Blood/ K3 EDTA (Lavender Top) 6 mL, 1 tube

Sub Mission Container (ภาชนะส่งตรวจ):

Whole blood EDTA, minimum volume 6 mL

Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):

Hemolyzed or clotted blood
Blood (or saliva) from patients who have had an allogeneic (non-self donor) bone marrow transplant
Blood (or saliva) from patients who have had an allogeneic (non-self donor) stem cell transplant
Blood (or saliva) from patients who had a blood transfusion less than two weeks prior to specimen collection

Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):

Specimen Type	Temperature	Time
Whole blood EDTA	Refrigerated, 2^oC to 8^oC	14 days
Saliva (2mL) in special collection kit *	Ambient	30 days

* Optional, Nurse can request the special collection kit from Lab 13th Floor, Tel. 14160-2
** Sending to USA

Test Code (รหัสการทดสอบ):

090-71-5552

Order Name (ชื่อการทดสอบ):

INVITAE Cancer screen (Proactive test) **

Method detail (วิธีการทดสอบ):

Next-generation sequencing (NGS)

Schedule (ตารางการทดสอบ):

N/A **Sent out to INVITAE, USA

Turnaround Time (ระยะเวลารอผล):

30 days

Performing Location (หน่วยงานที่ทำการทดสอบ):

INVITAE, USA
Referral Lab Services, Laboratory Department 14160-2

Test Code (รหัสการทดสอบ):

090-71-5552

Order Name (ชื่อการทดสอบ):

INVITAE Cancer screen (Proactive test) **

Clinical Information (ข้อมูลทางคลินิก):

The Invitae Cancer Screen analyzes more than 60 genes related to inherited cancers that, if detected early, may have effective medical interventions and preventive measures. Conditions tested include breast cancer, ovarian cancer, uterine cancer, colorectal cancer, cutaneous melanoma, gastric cancer, pancreatic cancer, prostate cancer, renal cell cancer, and thyroid cancer.

All genes included in the Cancer Screen can also be found in the Invitae Genetic Health Screen, which includes cardiovascular and cancer genes, as well as additional medically actionable conditions.

Please find example report from this link below
Cancer-screen-positive_Ex-Report.pdf

Reference Value (ค่าอ้างอิง):

An interpretive report will be provided.

Interpretation (การแปลผล):

Report integrate relevant guidelines to help develop a personalized screening and prevention plan for patients.

Clinical Reference (เอกสารอ้างอิง):