Latex agglutination based on immunologic reaction between DNP bound to biologically inrt latex particles and anti-DNP in test specimen.

Systemic lupus erythematosus (SLE), or lupus, is a nonspecific immune disorder. It is caused by antibodies, which are defense proteins that attack the body’s own tissues instead of foreign invaders. Lupus may affect a wide range of tissues, including joints, lungs, brain, heart, kidneys, and skin. This leads to a diverse array of symptoms

Individuals most often affected by lupus are adults, and currently, the disorder cannot be cured. However, with diet and lifestyle changes, in addition to medications to treat symptoms, the disorder may be effectively managed

An LE cell is either a neutrophil or a macrophage that has engulfed (phagocytized) degraded nuclear material from another cell. The engulfed nuclear material takes up Haematoxylin stain strongly; this strongly-stained engulfed nuclear material is called LE body

Detection of LE cell is made through microscopic examination. Specialized testing such as flow cytometric analysis can also detect LE cell in an automated manner
The LE Cell Blood Test is a screening test for lupus. It detects lupus cells. The test is used when lupus is suspected, but because it is less specific than other tests, it has mostly been replaced

The test was commonly used in the past to diagnose systemic lupus erythematosus. But currently, SLE is diagnosed by more sensitive and specific tests such as anti-nuclear antibody (ANA) blood test