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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
090-81-2023
Order Name (ชื่อการทดสอบ):
Leflunomide Metabolite (Teriflunomide), Serum **
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 2 tube

Collection Instructions:

1. Draw blood no sooner than 12 hours (trough value) after last dose.

2. Centrifuge within 2 hours of collection and aliquot serum into plastic vial.
 
Turnaround Time (ระยะเวลารอผล):
Receive specimen to report within 14 days
 
Useful For (ประโยชน์การทดสอบ):
Therapeutic monitoring of patients actively taking leflunomide

Assessment of elimination in patients requiring enhanced elimination of the drug
 
Methodology (วิธีการทดสอบ):
High-Turbulence Liquid Chromatography Mass Spectrometry (HTLC-MS/MS)
 
AliasesName (ชื่อเรียกอื่นๆ) :
A77 1726
Arava
Leflunomide
Leflunomide metabolite
Teriflunomide
 
 
 
Test Code (รหัสการทดสอบ):
090-81-2023
Order Name (ชื่อการทดสอบ):
Leflunomide Metabolite (Teriflunomide), Serum **
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain blood (Red top) 6 mL, 2 tube

Collection Instructions:

1. Draw blood no sooner than 12 hours (trough value) after last dose.

2. Centrifuge within 2 hours of collection and aliquot serum into plastic vial.
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 1 mL x 2 tubes
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic tube
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Ambient for 28 days
Frozen for 28 days 
Refrigerated for 28 days
 
 
 
Test Code (รหัสการทดสอบ):
090-81-2023
Order Name (ชื่อการทดสอบ):
Leflunomide Metabolite (Teriflunomide), Serum **
 
Schedule (ตารางการทดสอบ):
N/A **Sent Out to Mayo, USA
 
Turnaround Time (ระยะเวลารอผล):
Receive specimen to report within 14 days
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Mayo, USA
Referral Lab Services, Laboratory Department 14160-3
 
 
 
Test Code (รหัสการทดสอบ):
090-81-2023
Order Name (ชื่อการทดสอบ):
Leflunomide Metabolite (Teriflunomide), Serum **
 
 
Clinical Information (ข้อมูลทางคลินิก):
Leflunomide is a disease-modifying antirheumatic drug approved for therapy of rheumatoid arthritis and used off-label to reduce viral nephritis in renal transplant. It is a prodrug: rapid and complete metabolism converts leflunomide to its active metabolite, teriflunomide (also called A77 1726), which acts by inhibiting pyrimidine synthesis. Teriflunomide has a very long half-life, greater than 2 weeks on average.
 
Reference Value (ค่าอ้างอิง):
Therapeutic: >40 mcg/mL
Elimination: <0.020 mcg/mL
 
Interpretation (การแปลผล):
INTERPRETATION 
Therapy: clinical targets for serum teriflunomide (leflunomide metabolite) concentrations are still being determined, but levels greater than 40 mcg/mL appear to correlate with better outcome.
Elimination: serum concentrations less than 0.020 mcg/mL (20 ng/mL) are preferred to minimize potential teratogenesis for patients considering pregnancy.

CAUTIONS 
Leflunomide toxicity does not appear to correlate with teriflunomide concentrations, thus, this assay is unlikely to aid in evaluation of potential adverse drug reactions.
 
Clinical Reference (เอกสารอ้างอิง):
www.mayocliniclabs.com (Retrieved: 22 Jun 2022)