090-20-1560-01

Microalbuminuria, Urine 24-Hour

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1.ไม่มีภาวะขาดน้ำ หรือ ได้รับสารน้ำจำนวนมาก 
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3.ไม่ควรตรวจหลังผ่าตัดทันทีและไม่ควรออกกำลังกายก่อนตรวจ

24-hour urine, Clean containner with non preservative

Note:

• Please keep in refrigerated (2-8°C) during collection and transportation
• 24-hours volume is required.

24-hour urine, minimum volume 10 mL

Clean container

Specimen with preservative type will be reject

Specimen Type	Temperature	Time
24-hours urine	Refrigerated, 4oC	2 weeks
	Frozen, -70oC	5 months

090-20-1560-01

Microalbuminuria, Urine 24-Hour

Turbidimetric/Immunoturbidimetric

Tested daily (24 hours)

Collected specimen to report within 90 min

Chemistry, Laboratory Department Tel. 13224

7 days

090-20-1560-01

Microalbuminuria, Urine 24-Hour

Microalbuminuria is a condition characterized by increased urinary excretion of albumin in the absence of overt nephropathy, and can be used to predict diabetic nephropathy. Diabetic nephropathy is a major cause of death in individuals with insulin-dependent diabetes; and because it is accompanied by irreversible kidney damage and persistent proteinuria, it is a major factor in the decision to initiate hemodialysis. 
Early detection of glomerular damage, when it is minimal and reversible, is extremely important. Monitoring urinary microalbumin is an important component of treatment for both Type I and Type II diabetes mellitus.
Methods for monitoring microalbuminuria include measurement of protein excretion in 24 hour, timed, or overnight collections, and determination of the albumin:creatinine ratio in an untimed “spot” urine specimen. Twenty-four hour and timed urine collections may be associated with collection errors including improper timing, missed samples, and incomplete bladder emptying. The concentration of protein in a spot urine sample provides an estimate of the protein excretion rate, but is affected by patient hydration. The ratio of protein or albumin to creatinine in a spot urine sample corrects for variations in hydration and avoids the sources of error associated with 24 hour and timed urine collection.

 <30 mg/24 hrs

An albumin excretion rate of more than 30 mg/24 hours is considered to be microalbuminuric. By definition, the upper end of microalbuminuria is thought to be 300 mg/24 hours. Although this level has not been rigorously defined, it is felt that at this level it is more difficult to change the course of diabetic nephropathy. We have established normal values in our laboratory and agree with the 30 mg/24 hour level. A normal excretion rate of 20 mcg/minute has also been established in the literature and is consistent with our data. Thus, microalbuminuria has been defined at 30 to 300 mg/24 hours.

1. Manufacturer’s reagent package insert, Architect^® Microalbumin, Wako Pure Chemical Industries, Ltd. 2613-2 Oaza, Ogohara, Komono-cho Mie-gun, Mie 510-1222, Japan .
2. http://www.mayomedicallaboratories.com (Retrieved: 01 Jan 2019)