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ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก

Test Code (รหัสการทดสอบ):

090-31-4032

Order Name (ชื่อการทดสอบ):

Myasthenia Gravis Evaluation (ARBI with Reflex to MuSK), Serum **

Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):

Blood/ Plain blood (Red top) 6 mL, 2 tubes

Turnaround Time (ระยะเวลารอผล):

21 days

Useful For (ประโยชน์การทดสอบ):

Diagnosing autoimmune myasthenia gravis (MG) in adults and children.
Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders.
Establishing a quantitative baseline value that allows comparison with future levels if weakness is worsening.
(Anti-AChR, with Reflex to MUSK)

ORDERING GUIDANCE
This test should not be requested for patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.

Methodology (วิธีการทดสอบ):

ARBI, MUSK: Radioimmunoassay (RIA)
ACMFS: Flow Cytometry
MGMRI: Medical Interpretation

Test List In Profile (การทดสอบใน Profile):

Anti-AChR, with Reflex to MUSK

TESTING ALGORITHM
If acetylcholine receptor (AChR)-binding antibodies are greater than 0.02 nmol/L, then AChR muscle modulating antibody will be performed.

If AChR-binding antibodies are 0.02 nmol/L or less, then muscle-specific kinase (MuSK) autoantibody will be performed.

If unable to report AChR binding antibody due to interfering substances, then AChR muscle modulating antibody will be performed.

If unable to report AChR binding antibody due to interfering substances and AChR muscle modulating antibody is negative, then MuSK autoantibody will be performed.

Test Code (รหัสการทดสอบ):

090-31-4032

Order Name (ชื่อการทดสอบ):

Myasthenia Gravis Evaluation (ARBI with Reflex to MuSK), Serum **

Patient Preparation (การเตรียมตัวผู้ป่วย):

For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.

Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):

Blood/ Plain blood (Red top) 6 mL, 2 tubes

Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):

Serum, minimum volume 2-3 mL x 2 tubes

Sub Mission Container (ภาชนะส่งตรวจ):

Plastic tube

Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):

Serum Refrigerated or Frozen, 28 days

Test Code (รหัสการทดสอบ):

090-31-4032

Order Name (ชื่อการทดสอบ):

Myasthenia Gravis Evaluation (ARBI with Reflex to MuSK), Serum **

Schedule (ตารางการทดสอบ):

N/A **Sent Out to MAYO, USA

Turnaround Time (ระยะเวลารอผล):

21 days

Performing Location (หน่วยงานที่ทำการทดสอบ):

MAYO Laboratory
Referral Lab Services, Laboratory Department 14162

Test Code (รหัสการทดสอบ):

090-31-4032

Order Name (ชื่อการทดสอบ):

Myasthenia Gravis Evaluation (ARBI with Reflex to MuSK), Serum **

Reference Value (ค่าอ้างอิง):

Interpretation (การแปลผล):

Positive results in this antibody evaluation are indicative of autoimmune myasthenia gravis (MG). These results should be interpreted in the appropriate clinical and electrophysiological context.

In the presence of either acetylcholine receptor antibodies, a paraneoplastic basis should be considered with thymoma being the most frequently associated tumor with myasthenia gravis. Currently, muscle-specific kinase antibody positive MG is not associated with a paraneoplastic etiology.

Negative results do not exclude the diagnosis of an autoimmune neuromuscular junction disorder. If clinical suspicion remains and symptoms persistent or worsen, consider re-testing.

Clinical Reference (เอกสารอ้างอิง):