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HomeLab Services GuideTests
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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
090-10-1160
Order Name (ชื่อการทดสอบ):
PT mixing study
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Sodium citrate tube (Sodium Citrate 3.2% anticoagulant, Blue top) 3 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Collected specimen to report within 1 hour
 
Useful For (ประโยชน์การทดสอบ):
Screening test to detect a deficiency of 1 or more of the clotting factors of the extrinsic coagulation system (I, II, V, VII, X) due to hereditary deficiency or acquired conditions such as liver disease, vitamin K deficiency, or a specific factor inhibitor.
 
Methodology (วิธีการทดสอบ):
Clotting assay
 
AliasesName (ชื่อเรียกอื่นๆ) :
Prothrombin Time Mix 1:1
 
 
 
Test Code (รหัสการทดสอบ):
090-10-1160
Order Name (ชื่อการทดสอบ):
PT mixing study
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Sodium citrate tube (Sodium Citrate 3.2% anticoagulant, Blue top) 3 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Citrate plasma, minimum volume 0.5 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic tube
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: Hemoglobin >500 mg/dL
Lipemia: Triglyceride >1,000 mg/dL
Icterus: Bilirubin >30 mg/dL
Other: Clotted specimen will be rejected.
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Whole Blood, Sodium citrate Room temperature, 18oC to 25oC 4 hours
Plasma, Sodium citrate Room temperature, 18oC to 25oC 4 hours
Refrigerated, 2oC to 8oC 4 hours
Frozen, -20oC 2 weeks
Frozen, -70oC 1 year
 
 
 
Test Code (รหัสการทดสอบ):
090-10-1160
Order Name (ชื่อการทดสอบ):
PT mixing study
 
Method detail (วิธีการทดสอบ):
Clotting assay
 
Schedule (ตารางการทดสอบ):
Tested Daily (24 hours)
 
Turnaround Time (ระยะเวลารอผล):
Collected specimen to report within 1 hour
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Hematology, Laboratory department, Tel. 17254
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
14 days
 
 
 
Test Code (รหัสการทดสอบ):
090-10-1160
Order Name (ชื่อการทดสอบ):
PT mixing study
 
 
Clinical Information (ข้อมูลทางคลินิก):
The prothrombin time (PT) mix is only performed when the PT is abnormally prolonged. Please refer to test PTC / Prothrombin Time (PT), Plasma for an interpretation of results.
 
Interpretation (การแปลผล):
PT mixing study, using equal volume patient and normal pool plasma, may be performed on specimens with a prolonged PT to assist in differentiating coagulation factor deficiencies from coagulation inhibitors. Correction of the PT mix to within the normal reference range usually indicates a coagulation factor deficiency (normal plasma in the mixture ensures at least 50% activity of all coagulation factors). If the prolonged PT is due to an inhibitor (specific coagulation factor inhibitor, lupus anticoagulant, heparin, etc.), the PT mix typically fails to correct a prolonged PT. However, the presence of a weak inhibitor may be missed by the PT mixing study.

Accurate interpretation of both PT and PT mixing study results may often require additional testing. For example, the thrombin time (TT) test is helpful for identifying or excluding the presence of heparin, the platelet neutralization procedure (PNP, using a modified APTT method) for identifying or excluding lupus anticoagulant, the activated partial thromboplastin (APTT) and dilute Russell's viper venom time (DRVVT) for further assessment of the common procoagulant pathway, and coagulation factor assays to detect and identify deficient or abnormal factors. These assays are available as components of reflexive and interpretive testing panels in the Special Coagulation Laboratory (eg, PROCT / Prolonged Clot Time Profile).
 
Clinical Reference (เอกสารอ้างอิง):
  1. Manufacturer’s reagent package insert , RecombiPlasTin 2G,HemosILTM, Instrumentation Laboratory Company - Bedford, MA 01730-2443 (USA), Instrumentation Laboratory SpA - V.le Monza 338 - 20128 Milano (Italy) ; 09/2016
  2. https://www.mayocliniclabs.com (Retrieved: 22 Jan 2019)