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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก

Test Code (รหัสการทดสอบ):

LAB27

Order Name (ชื่อการทดสอบ):

Package BH MedGene

Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):

Buccal swab 1 swab

Document required:
1. Completed Consent form LAB-08170-Rev03-EN-Consent-for-Genomic-Medicine-Testing.pdf
2. Completed Requisition form Requisition-form_FOR-BI_Eng-20-May-2024_revised-5-June-2024.pdf

Turnaround Time (ระยะเวลารอผล):

Reported within 20-25 days
(exception for official holidays)

Useful For (ประโยชน์การทดสอบ):

Pharmacogenomics (PGx) lab testing has become increasingly useful for precision medicined as it help to tailor medicine treatment for individual person. This panel specifically identifies patients who may be at risk for altered metabolism of drugs that are modified by ABCG2, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, OPRM1, SLCO1B1, VKORC1

Methodology (วิธีการทดสอบ):

SNP genotyping is performed using open array technology. CYP2D6 copy number is established by real time PCR, allowing for quantification of up to 4 copies. 3D PCR is used to determine which allele is duplicated.

Test List In Profile (การทดสอบใน Profile):

ABCG2, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, OPRM1, SLCO1B1, VKORC1

AliasesName (ชื่อเรียกอื่นๆ) :

PGX, Pharmacogenetics, Pharmacogenomics, ABCG2, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, OPRM1, SLCO1B1, and VKORC1

Test Code (รหัสการทดสอบ):

LAB27

Order Name (ชื่อการทดสอบ):

Package BH MedGene

Patient Preparation (การเตรียมตัวผู้ป่วย):

Do not eat, drink (except for water), smoke, brush your teeth or chew gum for 1 hour before collecting the buccal sample

Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):

Buccal swab 1 swab

Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):

Buccal swab 1 swab

Sub Mission Container (ภาชนะส่งตรวจ):

Buccal swab

Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):

-No sticker label on swab.
-In the event where a sample was not adequately collected, damaged upon arrival to the lab or forms were not filled in their entirety you will be resupplied with a new myDNA test kit for sample recollection.

Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):

Buccal swab is ready to use and does not require additional preparation. It must be stored in its original package at a temperature between 2 and 30°C until the time of use. Do not overheat. Do not incubate or freeze prior to use. If incorrectly stored, its effectiveness will be compromised. Do not use after the expiry date clearly printed on the tube and on each single package. The sample must be collected immediately after opening the transparent bag.

Test Code (รหัสการทดสอบ):

LAB27

Order Name (ชื่อการทดสอบ):

Package BH MedGene

Turnaround Time (ระยะเวลารอผล):

Reported within 20-25 days
(exception for official holidays)

Performing Location (หน่วยงานที่ทำการทดสอบ):

Sent Out to MyDNA, Australia
Referral Lab Services, Laboratory Department 14160-2

Test Code (รหัสการทดสอบ):

LAB27

Order Name (ชื่อการทดสอบ):

Package BH MedGene

Clinical Information (ข้อมูลทางคลินิก):

Pharmacogenomics (PGx) lab testing has become increasingly useful in the managing of medications in clinical practice. By utilizing PGx lab test results, clinicians may now more accurately determine how a patient can metabolize certain medications to assist in identifying whether a medication will not work, work as expected or cause adverse drug reactions (ADRs) that may result in increased morbidity or mortality. This testing covers genes which control descriptive P-450 enzymes or CYP enzymes, primarily located in the small intestine and liver and sometimes other genes such as HLA genes. Pharmacogenomic (PGx) testing can help avoid adverse drug reactions (ADRs) or medication inefficacy by assisting in the adjustment of current or future medication doses. It can also help predict the best medications to use or those to avoid in advance by eliminating much of the existing dosing or medication selection method of trial and error

Please find example report from this link below
Example-Result_BH-MedGene-PGx-report_EN.pdf

Clinical Reference (เอกสารอ้างอิง):

1. Cacabelos R, Naidoo V, Corzo L, Cacabelos N, Carril JC. Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions. Int J Mol Sci. 2021 Dec 10;22(24):13302. doi: 10.3390/ijms222413302.