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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก

Test Code (รหัสการทดสอบ):

LAB43

Order Name (ชื่อการทดสอบ):

Package Lab Allergy genetic panel

Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):

Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 3 tube

Document required
Consent for Genetic Testing (LAB-08171)

Turnaround Time (ระยะเวลารอผล):

Report within 7-10 days

Useful For (ประโยชน์การทดสอบ):

This allergy genetic panel test provides information on the risk associated with allergy conditions including the allergy-induced by food and allergy that may affect one’s breathing conditions and skin conditions.

Assessing patients with suspected celiac disease who are currently (or have recently been) on a gluten-free diet, including interpretation for shrimp and peach allergy

This screening test could help determine the risks of allergies induced by food including peanut allergy and lactose intolerance, an allergy that affects breathing conditions including early childhood asthma, wheezing, and adult onset of asthma and chronic obstructive pulmonary disease (COPD), and allergy that affect skin conditions including atopic dermatitis and ichthyosis vulgaris.

Methodology (วิธีการทดสอบ):

HLA typing (PCR SSOP) และ Real-time PCR

Test List In Profile (การทดสอบใน Profile):

1. Peanut allergy
2. Lactose Intolerance
3. Early childhood asthma
4. Wheezing
5. Adult onset of asthma
6. COPD
7. Atopic dermatitis, and ichthyosis vulgaris
8. Celiac disease
9. Shrimp allergy
10. Peach allergy

AliasesName (ชื่อเรียกอื่นๆ) :

-HLA typing
-Celiac disease
-HLA for Celiac
-Allergy
-Allergy genetic
-SNP genotyping
-Peanut allergy
-Lactose Intolerance
-Early childhood asthma
-Wheezing
-Adult onset of asthma
-COPD
-Atopic dermatitis, and ichthyosis vulgaris
-Shrimp allergy
-Peach allergy
-DQ2
-DQ8

Test Code (รหัสการทดสอบ):

LAB43

Order Name (ชื่อการทดสอบ):

Package Lab Allergy genetic panel

Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):

Blood/ K3 EDTA (K3E) (Lavender Top) 3 mL, 3 tube

Document required
Consent for Genetic Testing (LAB-08171)

Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):

Whole blood, K3 EDTA (K3E) (Lavender Top) 3 mL

Sub Mission Container (ภาชนะส่งตรวจ):

K3 EDTA (K3E) (Lavender Top)

Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):

Use heparin as anticoagulant,
Severe clotted specimen

Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):

Refrigerated 2°C to 8°C for 7 days

Test Code (รหัสการทดสอบ):

LAB43

Order Name (ชื่อการทดสอบ):

Package Lab Allergy genetic panel

Turnaround Time (ระยะเวลารอผล):

Report within 7-10 days

Performing Location (หน่วยงานที่ทำการทดสอบ):

Research and Development Tel. 14252

Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):

3 months

Test Code (รหัสการทดสอบ):

LAB43

Order Name (ชื่อการทดสอบ):

Package Lab Allergy genetic panel

Clinical Information (ข้อมูลทางคลินิก):

HLA for Celiac disease is a genetic testing for HLA-DRB1, HLA-DQB1, and HLA-DQA1 alleles as a screening tool to determine risk for celiac disease, shrimp and peach allergy. The interpretation of HLA for Celiac disease is based on HLA-DQB1, and HLA-DQA1. The interpretation of HLA for shrimp and peach allergy is based on HLA-DRB1, and HLA-DQB1. HLA genotyping was performed by Laboratory for Pharmacogenomics, Faculty of Medicine Ramathibodi Hospital.

SNP genotyping for allergy genetic panel is a genetic testing for five single nucleotide polymorphisms (SNPs). This test is a screening tool to determine the risks for peanut allergy, lactose intolerance, early childhood asthma, wheezing, and adult onset of asthma and COPD, atopic dermatitis, and ichthyosis vulgaris. The interpretation of peanut allergy is based on intergenic SNP between HLA-DQB1 & HLA-DQA2 (rs9275596; T>C) and HLA-DRA (rs7192; G>T). The interpretation of lactose intolerance is based on MCM6 (rs4988235; G>A). The interpretation of early childhood asthma, wheezing, and adult onset of asthma and COPD are based on CDHR3 (rs6967330; G>A). The interpretation of atopic dermatitis, and ichthyosis vulgaris are based on FLG (rs61816761; G>A).

Clinical Reference (เอกสารอ้างอิง):

1.J A Tye-Din et al. Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective. Intern Med J. 2015 Apr;45(4):441-50.
2.Seik-Soon Khor et al. Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region. Sci Rep. 2018 Jan 18;8(1):1069.
3.Hong X, et al. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015 Feb 24;6:6304.
4.Baffour-Awuah NY, et al. Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry. J Pediatr Gastroenterol Nutr. 2015 Feb;60(2):182-91.
5.Bønnelykke K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet. 2014 Jan;46(1):51-5.
6.Basnet S, et al. CDHR3 Asthma-Risk Genotype Affects Susceptibility of Airway Epithelium to Rhinovirus C Infections. Am J Respir Cell Mol Biol. 2019 Oct;61(4):450-458.
7.Everman JL. Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations. J Allergy Clin Immunol. 2019 Oct;144(4):962-971.
8.Leung TF, et al. Cadherin-related family member 3 gene impacts childhood asthma in Chinese children. Pediatr Allergy Immunol. 2020 Feb;31(2):133-142.
9.Shigemasa R, et al. Genetic impact of CDHR3 on the adult onset of asthma and COPD. Clin Exp Allergy. 2020 Nov;50(11):1223-1229.
10.Wong XFCC, et al. Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants. J Allergy Clin Immunol. 2018 Feb; 141(2): 814–816.