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HomeLab Services GuideTests
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Overview
ข้อมูลทั่วไป Specimen
ข้อมูลสิ่งส่งตรวจ Performance
ข้อมูลการทดสอบ Clinical & Interpretation
ข้อมูลทางคลินิก
 
Test Code (รหัสการทดสอบ):
090-30-1420-01
Order Name (ชื่อการทดสอบ):
Vancomycin Level
 
Specimen / Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 90 min
 
Useful For (ประโยชน์การทดสอบ):
Used in the diagnosis and treatment of vancomycin overdose and in monitoring levels of vancomycin to help ensure appropriate therapy.
 
Methodology (วิธีการทดสอบ):
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
 
 
Test Code (รหัสการทดสอบ):
090-30-1420-01
Order Name (ชื่อการทดสอบ):
Vancomycin Level
 
Patient Preparation (การเตรียมตัวผู้ป่วย):
Follow by Physician or Pharmacist recommedation.
 
Collection Specimen Or Container (สิ่งส่งตรวจ/ภาชนะ):
Blood/ Plain Blood (Red Top) 6 mL, 1 tube
 
Specimen Testing Type (สิ่งส่งตรวจที่ใช้ในการทดสอบ):
Serum, minimum volume 0.5 mL
 
Sub Mission Container (ภาชนะส่งตรวจ):
Plastic vial
 
Rejection Criteria (เกณฑ์ปฏิเสธสิ่งส่งตรวจ):
Hemolysis: 4+ reject
 
Specimen Stabillity (ความคงตัวของสิ่งส่งตรวจ):
Specimen Type Temperature Time
Serum (keep in original tube) Room Temperature 8 hours
Serum Refrigerated, 2oC to 8oC 7 days
Frozen, -10oC 14 days
 
 
 
Test Code (รหัสการทดสอบ):
090-30-1420-01
Order Name (ชื่อการทดสอบ):
Vancomycin Level
 
Method detail (วิธีการทดสอบ):
Particle-enhanced turbidimetric inhibition immunoassay (PETINIA)
 
Schedule (ตารางการทดสอบ):
Tested daily (24 hours)
 
 
Turnaround Time (ระยะเวลารอผล):
Specimen collected to reported within 90 min
 
Performing Location (หน่วยงานที่ทำการทดสอบ):
Biochemistry, Laboratory Department Tel. 13224
 
Specimen Retention Time (ระยะเวลาเก็บสิ่งส่งตรวจ):
5 days
 
 
 
Test Code (รหัสการทดสอบ):
090-30-1420-01
Order Name (ชื่อการทดสอบ):
Vancomycin Level
 
 
Clinical Information (ข้อมูลทางคลินิก):
Vancomycin hydrochloride is a tricyclic glycopeptide derived from Amycolatopsis orientalis. It is commonly used in the treatment of methicillin-resistant Staphylococcus aureus infections. This glycopeptide inhibits the growth of the bacterium by intervening in the cell wall synthesis, thereby killing the bacterium. Extensive review articles have been published which fully examine vancomycin’s effectiveness and pharmacokinetics.
Vancomycin is absorbed minimally from the gastrointestinal tract. In the first 24 hours after intravenous dosing, the usual route of administration, about 90% of the vancomycin is excreted unchanged by the kidneys. The average half-life in patients with normal renal function is about 6 hours. Vancomycin is approximately 55% bound to plasma proteins. Therapeutic serum levels vary depending on the microorganism involved and the patient’s tolerance to the drug. Vancomycin serum or plasma concentrations are monitored to guide therapy, since individual patient differences require dose changes that are difficult to predict. Monitoring serum or plasma levels of vancomycin decreases the frequency of serious toxic effects.
 
Reference Value (ค่าอ้างอิง):
Therapeutic range = 20 - 40 ug/mL (Peak Level)
Therapeutic range = 10 - 20 ug/mL (Trough Level)
 
Clinical Reference (เอกสารอ้างอิง):
1. Manufacturer’s reagent package insert, Architect® Vancomycin, ABBOTT, Microgenics Corporation 46500 Kato Road, Fremont CA, 94538, USA.
2. Reference range: Vancomycin: Parenteral dosing, monitoring, and adverse effects in adults, Authors : Richard H Drew, PharmD, MS, FCCP, FIDPGeorge Sakoulas, MD. , https://www.uptodate.com/contents/vancomycin-parenteral-dosing-monitoring-and-adverse-effectsin-adults. (Retrieved: July2018)