090-21-1701

Vitamin K1, Serum **

Fasting overnight (12-14 hours) (infants-collect prior to next feeding)

Blood/ Plain blood (Red top) 6 mL, 2 tubes

Collection Instructions: Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.

Serum, minimum volume 2 mL

Plastic tube

Gross lipemia = Reject

Serum stability 30 days

090-21-1701

Vitamin K1, Serum **

Serum stability 30 days

Received specimen to reported within 14 days (official day)

Mayo, USA
Referral Lab Services, Laboratory Department

090-21-1701

Vitamin K1, Serum **

Vitamin K1, or phylloquinone, is part of a group of similar fat-soluble vitamins in which the 2-methyl-1,4-naphthoquinone ring is common. Phylloquinone is found in high amounts in leafy green vegetables and some fruits (avocado, kiwi). It is a required cofactor involved in the gamma-carboxylation of glutamate residues of several proteins. Most notably, the inactive forms of the coagulation factors prothrombin (factor II), factors VII, IX, and X, and proteins S and C are converted to their active forms by the transformation of glutamate residues to gamma-carboxyglutamic acid (Gla). Other proteins such as those involved in bone metabolism, cell growth, and apoptosis also undergo this Gla transformation. Measurement of vitamin K1 (phylloquinone) in fasting serum is a strong indicator of dietary intake and status.

<18 years: Not established
> or =18 years: 0.10-2.20 ng/mL

Low vitamin K1 concentrations in the serum are indicative of insufficiency and poor vitamin K1 status.

CAUTIONS 
Testing of nonfasting specimens or the use of vitamin K1 supplementation can result in elevated serum vitamin K1 concentrations.

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